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Virtual Pediatric Hospital: Paediapaedia: Persistent Fetal Circulation (PFC) Paediapaedia: Neonatal Chest Diseases

Persistent Fetal Circulation (PFC)

Michael P. D'Alessandro, M.D.
Peer Review Status: Internally Peer Reviewed


Clinical Presentation:
Profound progressive hypoxemia that is usually out of proportion to the radiographic evidence of pulmonary disease.

Etiology/Pathophysiology:
Persistent or recurrent pulmonary artery hypertension with right to left shunting through a patent foramen ovale and patent ductus arteriosus in a patient with pulmonary disease. Factors that increase pulmonary vascular resistance include acidosis, hypoglycemia, hypothermia, and polycythemia.

Pathology:
Not applicable.

Imaging Findings:
The CXR may be normal or can show changes of the underlying lung disease such as hyaline membrane disease, meconium aspiration syndrome, etc. A slightly enlarged heart may be seen along with slightly decreased pulmonary vascularity. icon gif

DDX:
Not applicable.

References:
See References Chapter.

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