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Michael P. D'Alessandro, M.D.
Peer Review Status: Internally Peer Reviewed
Etiology/Pathophysiology:
Caused by blood group incompatibilities between fetal and maternal
erythrocytes. The mother has been previously exposed to heterotypic
fetal erythrocytes and developed antibodies to them. When exposed
again to these heterotypic fetal erythrocytes the mother mounts an
immune response to them and her antibodies transplacentally enter the
fetal circulatory system and destroy the fetal erythrocytes, causing
a fetal anemia. The child is hypovolemic and in high output
congestive heart failure leading to cardiomegaly, hepatosplenomegaly,
anasarca, and ascites. Pulmonary edema is rare because of normal
fetal postnatal pulmonary hypertension.
Pathology:
Not applicable
Imaging Findings:
Hepatosplenomegaly, anasarca, ascites, cardiomegaly without pulmonary
edema, bell shaped thoracic
cage.
DDX:
Not applicable
References:
See References Chapter.
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