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Virtual Pediatric Hospital: Paediapaedia: Scurvey Paediapaedia: Musculoskeletal Diseases


Michael P. D'Alessandro, M.D.
Peer Review Status: Internally Peer Reviewed

Clinical Presentation:
Never seen prior to 6 months old and have tender extremities due to subperiosteal hemorrhage.

Due to Vitamin C deficiency which leads to defective osseous connective tissue formation with increased metaphyseal fragility and massive subperiosteal hemorrhage.

Not applicable

Imaging Findings:
On film see generalized demineralization, loss of normal trabeculae, and thin cortices. The growth plates are not widened and the metaphyses are smooth. The white line of Frankel is a dense zone of provisional calcification with a lucent band beneath this (scorbutic zone). There is extensive subperiosteal elevation and new bone reaction along the shafts of bones due to subperiosteal hemorrhage. The epiphyses are of normal size and shape and are surrounded by a dense ossification rim (Wimberger's ring).


See References Chapter.

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