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Virtual Pediatric Hospital: Paediapaedia: Rickets, Vitamin-D Resistant Paediapaedia: Musculoskeletal Diseases

Rickets, Vitamin-D Resistant

Michael P. D'Alessandro, M.D.
Peer Review Status: Internally Peer Reviewed


Clinical Presentation:
Presents from one year old with limb deformities and decreased growth. Males are more affected than females.

Etiology/Pathophysiology:
The causes of rickets include calcium deficiency due to Vitamin D deficiency or abnormality of metabolism, dietary calcium deficiency, phosphate deficiency due to decreased gut absorption or increased renal losses, neurofibromatosis, fluorosis, hypophosphatasia. In hypophosphatemic Vitamin D resistant rickets (renal rickets) the renal tubules can't resorb phosphorous.

Pathology:
Not applicable

Imaging Findings:
Radiographic changes are less severe than other types of rickets.

DDX:

References:
See References Chapter.

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