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Virtual Pediatric Hospital: Paediapaedia: Caffey Disease (Infantile Cortical Hyperostosis) Paediapaedia: Musculoskeletal Diseases

Caffey Disease (Infantile Cortical Hyperostosis)

Michael P. D'Alessandro, M.D.
Peer Review Status: Internally Peer Reviewed

Clinical Presentation:
Limited to first few months of life. Can be seen in newborns, can be familial. Presents with irritability, soft tissue swelling, underlying cortical thickening. Also see fever, pallor, pseudoparalysis.

Is a hyperostotic inflammatory reaction with the etiology unknown.

Not applicable

Imaging Findings:
Most frequently in mandible, ribs, clavicles, long bones, scapula, short tubular bones, pelvis. See a dense periosteal reaction.


Can tell them apart because in Caffey's the periosteal reaction is only diaphyseal in location and it spares the metaphyses and epiphyses.

See References Chapter.

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