Michael P. D'Alessandro, M.D.
Peer Review Status: Internally Peer Reviewed
Develops from primitive rhabdomyoblasts which are totipotential mesenchymal cells and is extremely malignant. It can arise anywhere in the body, but most commonly arises in the pelvis and genitourinary tract (39%) and in the head and neck (31%). There are three histological types: embryonal, alveolar, and pleomorphic. Embryonal and alveolar account for 90% of cases. Sarcoma botryoides is a type of embryonal that originates submucosally and then grows into the lumens of hollow organs. It grows rapidly, metastasizes early and wide with the exception of the embryonal type which infiltrates and recurs locally.
It can appear as a solid infiltrative lesion or as a polypoid intraluminal mass that arises in the base of the bladder or in the region of the bladder trigone. Partial distal ureteral obstruction is often seen.
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