Michael P. D'Alessandro, M.D.
Peer Review Status: Internally Peer Reviewed
Tranmission as autosomal dominant, but 50% of cases arise spontaneously. The lesions start off being sessile and become pedunculated over time. The polyps are adenomatous with malignant potential and need treatment via a total colectomy as 95% of patients who do not have a colectomy develop colon carcinoma by the 5th decade. The most frequently involved site is the sigmoid.
On an air contrast enema in older patients multiple polyps of relatively uniform size and configuration are seen, ranging from 2-4 millimeters in diameter, that coat the colonic mucosa. In younger patients you may only see serrations of the colonic mucosa that resembles ulcerative colitis.
See References Chapter.
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