Michael P. D'Alessandro, M.D.
Peer Review Status: Internally Peer Reviewed
Etiology is unknown. Have transmural inflammation of the bowel wall with multiple longitudinal and transverse ulcerations of the mucosa forming a cobble stone pattern with skip areas. May affect any site in the GI tract, but the small bowel is the primary disease site in children, usually with ileocolic involvement. Eleven percent have isolated colonic disease, and total colonic disease is rare. Fistulas are common because the disease is transmural and are often seen in the perianal region.Carcinoma is unusual.
Transmural inflammation characterized by scattered granulomas containing mononuclear and multinucleated giant cells seen in bowel wall and adjacent lymphnodes.
Small bowel involvement is characterized by hypermotility and thickened and coarsened mucosal folds. Seventy percent have small bowel disease, and the terminal ileum is the most commonly involved site in the GI tract. The earliest manifestations in the colon are small irregular nodules with accentuation of haustral markings. Later, "cobble stoning" from deep crisscross ulcers which may penetrate the bowel wall are seen. The rectum is normally spared. There can be multicentric involvement, with normal areas in between, so called "skip lesions." Strictures can develop in chronic disease along with fistulas.
Section Top | Title Page
Please send us comments by filling out our Comment Form.
All contents copyright © 1992-2014 Donna M. D'Alessandro, M.D. and Michael P. D'Alessandro, M.D. and the authors. All rights reserved.
"Virtual Pediatric Hospital", the Virtual Pediatric Hospital logo, and "A digital library of pediatric information" are all Trademarks of Donna M. D'Alessandro, M.D. and Michael P. D'Alessandro, M.D.
Virtual Pediatric Hospital is funded in whole by Donna M. D'Alessandro, M.D. and Michael P. D'Alessandro, M.D. Advertising is not accepted.
Your personal information remains confidential and is not sold, leased, or given to any third party be they reliable or not.
The information contained in Virtual Pediatric Hospital is not a substitute for the medical care and advice of your physician. There may be variations in treatment that your physician may recommend based on individual facts and circumstances.
This site complies with the HONcode standard for trustworthy health information: